New cephalosporins with 7-acyl groups derived from .BETA.-ketoacids. II. Further modifications of 7-(3-oxobutyrylamino)-cephalosporins.
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منابع مشابه
Cephalosporins IV. Synthesis and structure-activity relationships of new 7 alpha-methoxy-7 beta-vinylenethioacetamido cephalosporins.
The synthesis and in vitro activity of 7 alpha-methoxy-7 beta-vinylenethioacetamido cephalosporins with various substituents at the 3-position are described. These cephalosporins showed good activity against beta-lactamase producing Gram-negative bacteria. 7 alpha-Methoxy-7-[(Z)-beta-cyano-vinylenethioacetamido]-3-[(1-methyl-1H-tetrazol -5-yl)thiomethyl]-3-cephem-4-carboxylic acid (3) was sever...
متن کاملPotent cephalosporinase inhibitors: 7 beta-[2-(1, 3-dithiolan-2-ylidene) acetamido] cephalosporins and related compounds.
Cephalosporins possessing a 1, 3-dithiolane, 1, 3-dithiane, or 1, 3-dithietane ring on their 7 beta-substituents showed potent inhibitory activity against cephaloridine hydrolysis by cephalosporinases purified from proteus morganii, Proteus rettgeri, and Proteus inconstans, which were not inhibited by clavulanic acid, a well-known beta-lactamase inhibitor. The mode of inhibition was competitive...
متن کاملPossibilities to acylate 7-aminocephalosporanic acid to obtain some cephalosporins.
AIM Acylation of 7-aminocephalosporanic acid with an adequate acyl chloride in order to obtain cefotaxime sodium salt. MATERIAL AND METHODS Cefotaxime sodium salt was synthesized by acylating 7-amino cephalosporanic acid with 2-[2'-chloracetamidothiazole-4-yl]-2-(syn)-methoxy-imino acetic chloride in four steps. The melting point was determined, and IR spectral analysis and elemental analysis...
متن کاملCephalosporins. VII. Synthesis and antibacterial activity of new cephalosporins bearing a 2-imino-3-hydroxythiazoline (2-aminothiazole N-oxide) in the C-7 acylamino side chain.
Introduction of a hydroxyl group into the thiazole ring nitrogen of cephalosporins belonging to the cefotiam and cefotaxime families gave rise to products, better described by the tautomeric N-oxide form, which proved particularly active against Gram-negative bacteria. Cephems bearing a (Z)-alkoxyimino functionality are of special interest for broadness of spectrum; among them, 7 beta-[(Z)-2-(2...
متن کاملSensitivity tests with cephalosporins.
The sensitivity of 127 strains of miscellaneous Gram-negative bacilli to various cephalosporins was determined by three methods. Disc tests with cephaloridine (CLOR), cephalothin (CTIN) and cephalexin (CLEX) made most strains of beta-lactamase-producing Escherichia coli appear sensitive. Eight cephalosporins were tested by the agar break-point method using concentrations of 16 and 4 mg/l for al...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1978
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.31.1252